69582-95-2Relevant academic research and scientific papers
SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS
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Page/Page column 157-158, (2010/02/07)
Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists to relieve symptons, associated with bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.
Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.
Simeone, Joseph P,Bugianesi, Robert L,Ponpipom, Mitree M,Yang, Yi Tien,Lo, Jane-Ling,Yudkovitz, Joel B,Cui, Jisong,Mount, George R,Ren, Rena Ning,Creighton, Mellissa,Mao, An-Hua,Vincent, Stella H,Cheng, Kang,Goulet, Mark T
, p. 3329 - 3332 (2007/10/03)
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs.
