69589-00-0Relevant academic research and scientific papers
Superacid-promoted reactions of N-acyliminium ions: An effective route to substituted 3-oxo-1,2,3,4-tetrahydroisoquinolines and related products
Zhang, Yiliang,Kindelin, Patrick J.,DeSchepper, Daniel J.,Zheng, Chong,Klumpp, Douglas A.
, p. 1775 - 1780 (2006)
Intramolecular cyclizations involving N-acyliminium ions are shown to give products in good yields from reactions with CF3SO3H (triflic acid). The resulting 3-oxo-1,2,3,4-tetrahydroisoquinolines have been converted in high yields to 1,2-diaryl-1,2,3,4-tetrahydroisoquinolines, which have been recently shown to be selective estrogen receptor modulators. In a reaction using a chiral N-acyliminium ion, cyclization is found to occur in moderately high diastereoselectivity. Several examples of intermolecular triflic acid-promoted reactions are also reported. Georg Thieme Verlag Stuttgart.
