6959-53-1Relevant academic research and scientific papers
Modelling, synthesis and biological evaluation of novel glucuronide-based probes of Vibrio cholerae sialidase
Mann, Maretta C.,Thomson, Robin J.,Dyason, Jeffrey C.,McAtamney, Sarah,Von Itzstein, Mark
, p. 1518 - 1537 (2006)
The development of sialidase inhibitors is an area of continuing interest due to their potential use as therapeutic agents to combat viral and bacterial infections. Herein, we report our studies involving the sialidase from the pathogen Vibrio cholerae, t
SHORT-CHAIN FATTY ACID HEXOSAMINE ANALOGS AND THEIR USE IN TISSUE ENGINEERING APPLICATIONS
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Paragraph 0108, (2014/10/18)
A new class of molecules, C1-OH tributanoylated hexosamines, including, for example, Ga1NAc, G1cNAc and ManNAc, are demonstrated to increase cartilage-like tissue accumulation by IL- 1β-stimulated chondrocytes. Furthermore, all three molecules
Synthesis of five nona-β-(1→6)-d-glucosamines with various patterns of N-acetylation corresponding to the fragments of exopolysaccharide of Staphylococcus aureus
Yudina, Olga N.,Gening, Marina L.,Tsvetkov, Yury E.,Grachev, Alexey A.,Pier, Gerald B.,Nifantiev, Nikolay E.
experimental part, p. 905 - 913 (2011/06/20)
A series of five 3-acetamidopropyl β-glycosides of nona-β-(1→6)-glucosamines containing two N-acetylglucosamine residues separated by a different number of glucosamine units with free amino groups have been synthesized using a convergent blockwise approac
HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS
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Page/Page column 50-51, (2009/07/03)
Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors
Mann, Maretta C.,Thomson, Robin J.,Von Itzstein, Mark
, p. 5555 - 5558 (2007/10/03)
The synthesis of Neu5Ac2en mimetics as inhibitors of Vibrio cholerae sialidase is reported. A novel approach to the synthesis of β-glycosides of N-acetyl-d-glucosaminuronic acid, in six steps and good overall yield from N-acetyl-d-glucosamine, has been de
The reaction of partially protected aldoses with stabilized arsonium ylides: Synthesis of E acyclic unsaturated derivatives and C-glycosyl derivatives
Lievre, Catherine,Frechou, Catherine,Demailly, Gilles
, p. 1 - 15 (2007/10/03)
The reaction of partially protected aldoses with (carbomethoxymethyl)triphenylarsonium bromide and zinc in toluene gave E α,β-unsaturated acyclic esters. When intramolecular transesterification occurred, bicyclic 1,4-lactone derivatives were formed concurrently. Otherwise, using these non alcaline conditions, olefination did not favour the formation of C-glycosyl derivatives. On the other hand, when the reaction was performed with (carbomethoxymethylene)triphenylarsorane in toluene, followed by the addition of n-butyllithium, bicyclic derivatives were obtained rapidly in good yields. Moreover, when cyanomethyltriphenylarsonium bromide was used in place of (carbomethoxymethyl)triphenylarsonium bromide, the corresponding E aldooctenonitriles were produced in satisfactory yields.
FLUORINATED CARBOHYDRATES AS POTENTIAL PLASMA MEMBRANE MODIFIERS AND INHIBITORS. SYNTHESIS OF 2-ACETAMIDO-2,6-DIDEOXY-6-FLUORO-D-GALACTOSE
Sharma, Moheswar,Potti, Gopalan G.,Simmons, Onda D.,Korytnyk, Walter
, p. 41 - 52 (2007/10/02)
Reaction of benzyl 2-acetamido-3,4-di-O-benzyl-2-deoxy-6-O-mesyl-α-D-galactopyranoside with cesium fluoride gave benzyl 2-acetamido-3,6-anhydro-4-O-benzyl-2-deoxy-α-D-galactopyranoside instead of the desired 6-fluoro derivative.Acetonation of benzyl 2-ace
