69612-72-2Relevant academic research and scientific papers
Enkephalin analogs and a process for the preparation thereof
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, (2008/06/13)
The invention relates to new enkephalin analogues of the general formula (I), wherein Tyr, Gly and Phe represent L-tyrosyl, glycyl and L-phenylalanyl residue, respectively, X is glycyl residue or a D-α-aminocarboxylic acid residue with a lower alkyl, lowe
N-Adamantane-substituted tetrapeptide amides
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, (2008/06/13)
N-Adamantane-substituted tetrapeptide amides and the pharmacologically acceptable salts thereof are disclosed herein. These compounds are analogs of enkephalin wherein the methionine or leucine of position 5 has been substituted by an adamantyl amide and the glycine of position 2 has been substituted by various amino acid residues. Optionally the tyrosine of position 1 and the phenylalanine of position 4 may be substituted by various amino acid residues. These compounds exhibit agonist activity at opiate receptor sites and are useful as analgesics.
Synthesis and pharmacological study of some enkephalin analogs in relation to the plurality of opiate receptors
Audigier,Mazarguil,Gout,Cros
, p. 173 - 177 (2007/10/02)
We have synthesized a series of enkephalin analogs and measured their affinity for each type of 'opiate' receptor, the μ receptor and the δ receptor. Furthermore, we have determined their respective antinociceptive activity after intracerebroventricular i
