69617-56-7

Upstream product

• 1443440-55-8 N-(m-tolyloxy)acetamide 
• 104-87-0 4-methyl-benzaldehyde 
• 69617-51-2 2-bromo-4,4'-dimethyl-benzophenone (Z)-oxime 

Downstream Products

• 69847-69-4 6-(trans-2-biphenyl-4-yl-vinyl)-3-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-benzo[d]isoxazole 
• 69617-34-1 6-(3-methoxy-trans-styryl)-3-[4-(3-methoxy-trans-styryl)-phenyl]-benzo[d]isoxazole 
• 69617-32-9 6-(4-isopropyl-trans-styryl)-3-[4-(4-isopropyl-trans-styryl)-phenyl]-benzo[d]isoxazole 
• 69617-28-3 6-trans-styryl-3-(4-trans-styryl-phenyl)-benzo[d]isoxazole 

Relevant academic research and scientific papers

Palladium-catalyzed benzo[d]isoxazole synthesis by C-H activation/[4 + 1] annulation

We report a palladium-catalyzed intermolecular [4 + 1] annulation pathway for N-phenoxyacetamides with aldehydes to form 1,2-benzisoxazoles. By activating the C-H bonds ortho to phenol-derived O-N bonds, the method enables the simultaneous construction of C-C and CN bonds in 1,2-benzisoxazoles with the O-N bonds intact. The method has been successfully applied to the synthesis of active pharmaceutical intermediates, such as risperidone.