69619-22-3Relevant academic research and scientific papers
A facile transformation of amino acids to functionalized coumarins
Bandyopadhyay, Anupam,Gopi, Hosahudya N.
, p. 8089 - 8095 (2011)
The synthesis of novel chiral coumarins functionalized with proteinogenic amino acid side chains via N-protected γ-amino-β-keto esters and their incorporation into the cell permeable HIV-1 TAT peptide through the modified solid phase peptide synthesis are
Tin(ii) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement
Bandyopadhyay, Anupam,Agrawal, Neha,Mali, Sachitanand M.,Jadhav, Sandip V.,Gopi, Hosahudya N.
experimental part, p. 4855 - 4860 (2010/12/24)
A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(ii) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction is mild, instantaneous and compatible with Boc-, Fmoc- and Cbz-amino protecting groups.
Syntheses and structure-activity studies of analogues and γ-aminobutyric acid (GABA)
Honore,Hjeds,Krogsgaard-Larsen,Christiansen
, p. 429 - 434 (2007/10/07)
The syntheses of (2RS,4RS)- and (2RS,4SR)-2-hydroxy-4-aminopentanoic acid, (3RS,4R)- and (3RS,4S)-3-hydroxy-4-aminopentanoic acid, (RS)-3-hydroxy-5-aminopentanoic acid, trans-(R)- and trans-(S)-4-amino-2-pentenoic acid and trans-5-amino-2-pentenoic acid are described. The compounds were tested as inhibitors of the binding of 3H-GABA to receptor sites on membranes from rat brains and some of the compounds were tested as inhibitors of the >-uptake to GABA into rat brain slices.
