69624-11-9

Basic information

• Product Name: 3-Chloropyrrole
• Synonyms: 3-chloro-1H-pyrrole
• CAS NO: 69624-11-9
• Molecular Formula: C₄H₄ClN
• Molecular Weight: 101.5343
• Product Categories: Benzenes
• Mol File: 69624-11-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 181.225 °C at 760 mmHg
• Flash Point: 79.106 °C
• Appearance: /
• Density: 1.274 g/cm³
• CAS DataBase Reference: 3-Chloropyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloropyrrole(69624-11-9)
• EPA Substance Registry System: 3-Chloropyrrole(69624-11-9)

Safety Data

• Hazardous Substances Data: 69624-11-9(Hazardous Substances Data)

Usage

Uses

3-Chloro-1H-pyrrole is a useful reactant and reagent for organic reactions and synthesis.

Upstream product

• 130408-83-2 3-chloro-1-(triisopropylsilyl)-1H-pyrrole 
• 80263-41-8 1-chloro-1H-pyrrole 
• 109-97-7 pyrrole 

Downstream Products

• 1623751-92-7 (3-chloro-1H-indol-7-yl)(4-methoxyphenyl)methanone 
• 1623751-91-6 (3-chloro-1H-indol-7-yl)(p-tolyl)methanone 

Relevant articles and documents

MALT1 INHIBITORS AND USES THEREOF

The invention provides compounds of formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the specification which are potent inhibitors of the enzyme MALT1 and are useful in the treatment of autoimmune disorders and diseases and as an immunooncology approach to the treatment of cancer, especially bladder cancer, colon cancer, hepatocellular cancer and small cell or non-small cell lung cancer.

Acid Catalyzed Chlorination of Pyrrole With N-Chloroacetanilide

The chlorination of pyrrole with N-chloroacetanilide was catalyzed by acetic acid.Transfer of Cl+ occurred directly to the α and β positions of pyrrole and a mixture of 2-chloro-, 3-chloro- and 2,5-dichloropyrrole was formed.The α/β ratio was 10:1 under competitive conditions.