69637-20-3Relevant academic research and scientific papers
Exclusive α-coupling in the aldol reaction of unsaturated trimethylsilyl esters: An efficient and practical direct synthesis of unsaturated β-hydroxy acids
Bellassoued, Moncef,Grugier, Jerome,Lensen, Nathalie,Catheline, Audrey
, p. 5611 - 5615 (2007/10/03)
The lithium enolates of trimethylsilyl but-3-enoate and 3-methylbut-3-enoate reacted with aldehydes and saturated or aromatic ketones at -70°C to give exclusively the α-condensation products in excellent yields. The unsaturated β-hydroxy acids thus obtained were directly identified, and the usual conversion into their methyl esters with diazomethane was not necessary. Unsaturated ketones underwent Michael reaction through α-addition leading to the unsaturated 5-oxo acids.
SUR LA REACTION DE REFORMATSKY. II-PREPARATION ET REACTIVITE DE L'ORGANOZINCIQUE ISSUS DU SEL BROMOZINCIQUE DE L'ACIDE γ-BROMOSENECIOIQUE.
Bellassoued, M.,Habbachi, F.,Caudemar, M.
, p. 1785 - 1792 (2007/10/02)
The condensation of benzaldehyde and cyclohexanone with the bromozinc salt derived from γ-bromosenecioic acid, in the presence of zinc, yield unsaturated hydroxyacids or lactones.The equilibration of the intermediary alcoxides is studied.
