6965-44-2

Usage

Uses

Used in Pharmaceutical Industry:
(1-methyl-1H-indol-3-yl)methanol is used as a pharmaceutical agent for its antimicrobial, anti-inflammatory, and antitumor properties. It has been investigated for its potential applications in the field of medicine, particularly for its ability to target various types of infections and inflammations, as well as its potential to inhibit tumor growth.
Used in Organic Synthesis:
(1-methyl-1H-indol-3-yl)methanol is used as a building block in organic synthesis for the development of new drug candidates. Its unique structure and properties make it a valuable component in the creation of novel compounds with potential therapeutic applications.
Used in Research and Development:
(1-methyl-1H-indol-3-yl)methanol is used as a research compound for studying its potential biological and pharmacological activities. This allows scientists to explore its mechanisms of action and identify new therapeutic targets for the development of innovative treatments.

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 19012-03-4 N-methyl-3-formylindole 

Downstream Products

• 318-54-7 2,2,2-trifluoro-1-(1-methyl-1H-indol-3-yl)ethan-1-one 
• 136672-24-7 (4-methoxyphenyl)(1-methyl-3-indolyl)methane 
• 19012-03-4 N-methyl-3-formylindole 

Relevant academic research and scientific papers

Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis

Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl,gem-dimethyl and carbonyl groups has been demonstrated to often improve chemical properties of target molecules for drug discovery purposes. The investigation of the properties of 3,3-diaryloxetanes, particularly of interest as a benzophenone replacement, remains largely unexplored. With recent synthetic advances in accessing this motif we studied the effects of 3,3-diaryloxetanes on the physicochemical properties of ‘drug-like’ molecules. Here, we describe our efforts in the design and synthesis of a range of drug-like compounds for matched molecular pair analysis to investigate the viability of the 3,3-diaryloxetane motif as a replacement group in drug discovery. We conclude that the properties of the diaryloxetanes and ketones are similar, and generally superior to related alkyl linkers, and that diaryloxetanes provide a potentially useful new design element.

Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids

The palladium-catalyzed synthesis of indole/benzofurancontaining diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.