696583-48-9Relevant academic research and scientific papers
α-amino-β-sulfonyl hydroxamic acid compounds
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, (2008/06/13)
A family of molecules is disclosed that inhibit matrix metalloprotease (MMP) activity, and particularly inhibit the activity of one or more of MMP-2, MMP-9, or MMP-13, while generally exhibiting little activity against MMP-1. A contemplated compound also
α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1
Becker, Daniel P,Barta, Thomas E,Bedell, Louis,DeCrescenzo, Gary,Freskos, John,Getman, Daniel P,Hockerman, Susan L,Li, Madeleine,Mehta, Pramod,Mischke, Brent,Munie, Grace E,Swearingen, Craig,Villamil, Clara I
, p. 2719 - 2722 (2007/10/03)
A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and selectivity versus MMP-1. Various substituents were employed on the α-amino group (P1 position), as well as different groups attached to the su
