6966-87-6

Basic information

• Product Name: (2E)-2-(HYDROXYIMINO)-N-(3-METHOXYPHENYL)ACETAMIDE
• Synonyms: m-Glyoxylanisidide,2-oxime (8CI); m-Glyoxylanisidide, oxime (6CI);2-Hydroxyimino-N-(3-methoxyphenyl)acetamide; NSC 68224
• CAS NO: 6966-87-6
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• Mol File: 6966-87-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.22g/cm³
• Refractive Index: 1.549
• CAS DataBase Reference: (2E)-2-(HYDROXYIMINO)-N-(3-METHOXYPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-(HYDROXYIMINO)-N-(3-METHOXYPHENYL)ACETAMIDE(6966-87-6)
• EPA Substance Registry System: (2E)-2-(HYDROXYIMINO)-N-(3-METHOXYPHENYL)ACETAMIDE(6966-87-6)

Safety Data

• Hazardous Substances Data: 6966-87-6(Hazardous Substances Data)

Usage

General Description

The chemical compound (2E)-2-(hydroxyimino)-N-(3-methoxyphenyl)acetamide is a derivative of acetamide with a hydroxyimino group attached at the 2 position and a 3-methoxyphenyl group attached at the N position. It has potential pharmaceutical applications due to its structure, which suggests possible interactions with biological targets such as enzymes or receptors. The compound's specific properties and potential uses would need to be determined through further research and testing.

InChI:InChI=1/C9H10N2O3/c1-14-8-4-2-3-7(5-8)11-9(12)6-10-13/h2-6,13H,1H3,(H,11,12)/b10-6-

Upstream product

• 536-90-3 m-Anisidine 
• 75-87-6 chloral 

Downstream Products

• 7699-19-6 6-methoxyoxindole 

Relevant articles and documents

MACROCYCLIC SERINE PROTEASE INHIBITORS

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors

A series of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones were prepared and tested for aldose reductase inhibitory activity. The 6'- halogenated derivatives were found to be highly potent in vitro inhibitors of male rabbit lens aldose reductase and in vivo inhibitors of polyol accumulation in the sciatic nerves of galactosemic rats. Of these, (4R)-6'- chloro-3'-methylspiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-trione (67) showed the most potent in vitro and in vivo activities. An oral dose of 3 g/kg of compound 67 caused neither death nor behavioral abnormality in the preliminary acute toxicity study using mice and rats. Compound 67 was selected as a candidate for further evaluation. The quantitative structure- activity relationships in this series are also discussed.