696650-95-0Relevant academic research and scientific papers
Synthesis and Biological Activity of Substituted Spiro[chromene-4,3′-indoles] and Spiro[indole-3,4′-quinolines]
Pogosyan,Pogosyan,Aleksanyan,Safaryan,Arakelyan
, p. 1860 - 1863 (2018)
New substituted spiro[chromene-4,3′-indoles] and spiro[indole-3,4′-quinolines] have been synthesized in 35–65% yields by one-pot regioselective three-component condensation of N-substituted isatins with two active methylene compounds.
Efficient one-pot synthesis of spirooxindole derivatives bearing hexahydroquinolines using multicomponent reactions catalyzed by ethylenediamine diacetate
Kang, Sorang,Lee, Yongrok
, p. 2593 - 2599 (2013/09/24)
A simple and efficient one-pot synthesis of biologically interesting spirooxindole derivatives bearing hexahydroquinoline skeleton was accomplished by EDDA-catalyzed, three-component reactions between isatins, malononitrile, and enaminones in good yields. The value of this methodology lies in its inexpensive and nontoxic organocatalyst, mild reaction conditions, and ease of handling.
