696661-90-2Relevant academic research and scientific papers
Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents
Raval, Preeti,Jain, Mukul,Goswami, Amitgiri,Basu, Sujay,Gite, Archana,Godha, Atul,Pingali, Harikishore,Raval, Saurin,Giri, Suresh,Suthar, Dinesh,Shah, Maanan,Patel, Pankaj
, p. 3103 - 3109 (2011/06/24)
In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, novel thiophene substituted oxazole containing α-alkoxy-phenylpropanoic acid derivatives are designed as highly potent PPARα/γ dual agonists. These compounds were found to be efficacious at picomolar concentrations. Lead compound 18d has emerged as very potent PPARα/γ dual agonist demonstrating potent antidiabetic and lipid lowering activity at a very low dose and did not exhibit any significant signs of toxicity in rodents.
SUBSTITUTED ARALKYL DERIVATIVES
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Page 49, (2008/06/13)
The present invention relates to novel substituted aralkyl derivatives of the general formula (I) and (IIIa), their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, ph
