696664-23-0Relevant academic research and scientific papers
Synthesis of electronically deficient atropisomeric bisphosphine ligands and their application in asymmetric hydrogenation of quinolines
Zhang, De-Yang,Wang, Duo-Sheng,Wang, Min-Can,Yu, Chang-Bin,Gao, Kai,Zhou, Yong-Gui
, p. 2796 - 2802 (2011)
A series of electronically deficient atropisomeric bisphosphine ligands have been synthesized from (S)-MeO-BiPhep. The introduction of electron-withdrawing groups in the ligands had a dramatic influence on both the enantioselectivity and the activity of catalyst. The iridium complex of the MeO-BiPhep-based ligand bearing a trifluoromethanesulfonyl group was successfully applied in the asymmetric hydrogenation of quinolines with ee values of up to 95% and turnover numbers (TON) of up to 14,600. Georg Thieme Verlag Stuttgart, New York.
The enantioselective total synthesis of alkaloid (-)-galipeine
Yang, Peng-Yu,Zhou, Yong-Gui
, p. 1145 - 1149 (2007/10/03)
The first total synthesis of (-)-galipeine was accomplished in seven steps with 54% overall yield from isovanillin based on Ir-catalyzed asymmetric hydrogenation of a quinoline derivative as a key step, with its absolute stereochemistry being established.
