69676-22-8Relevant academic research and scientific papers
Direct β-C(sp3)-H Functionalization of Aliphatic Amines to α,β-Unsaturated Imines, Aldehydes, and Chromenes
Mandal, Sumana,Mahato, Sujit,Jana, Chandan K.
supporting information, p. 3762 - 3765 (2015/08/18)
A metal-free method for direct β-C(sp3)-H functionalization of aliphatic amine was developed. The method is based on a reaction that yields enamine directly from the corresponding aliphatic amine, which otherwise requires the aid of metallic reagent and/or external oxidant. The reaction is operationally simple, general, and highly efficient in functionalizing both cyclic and acyclic amines. Structurally diverse unsaturated imines were obtained from N-heterocycles, while acyclic amines provided 2-alkyl cinnamaldehyde and benzopyran derivatives with excellent E/Z-selectivity.
Ruthenium-catalyzed direct amination of alcohols with tertiary amines
Luo, Jiaying,Wu, Mingyue,Xiao, Fuhong,Deng, Guojun
experimental part, p. 2706 - 2709 (2011/06/19)
A highly selective phosphine-based ruthenium catalyst system efficiently catalyzes the direct amination of alcohols with aliphatic tertiary amines, yielding unsymmetric tertiary amines in yields up to 87%. Ligand and solvent both affect the reaction yields significantly. The reaction can be performed with a wide variety of functionalities.
