6968-92-9

Usage

InChI:InChI=1/C10H6N2O/c11-6-8(7-12)5-9-3-1-2-4-10(9)13/h1-5,13H

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 109-77-3 malononitrile 
• 90-02-8 salicylaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 4559-70-0 Diphenylphosphine oxide 
• 90-01-7 salicylic alcohol 
• 779-84-0 N-phenylsalicylaldimine 

Downstream Products

• 15119-34-3 3-cyanocoumarin 
• 98664-33-6 5-thiazolidine-2,4-dithione 
• 86273-68-9 α-cyano-β-(2-hydroxyphenyl)thioacrylamide 
• 1190289-89-4 4-amino-2-(2-hydroxyphenyl)-1,2-dihydropyrimido[1,2-a]benzimidazole-3-carbonitrile 
• 1234708-20-3 4-[2-amino-3-cyano-4-(2-hydroxyphenyl)-5,6,7,8-tetrahydroquinolin-1(4H)-yl]benzenesulfonamide 
• 1386373-75-6 4-[2-amino-3-cyano-5-oxo-4-(2-hydroxyphenyl)-4H-indeno[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide 
• 1338245-66-1 1-(1-(1H-benzo[d]imidazol-2-yl)ethylideneamino)-6-amino-4-(2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 1431621-16-7 6-amino-1-((1,3-diphenyl-1H-pyrazole-4-yl)methyleneamino)-4-(2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 1463460-81-2 5-amino-3-(2-hydroxyphenyl)-1-phenyl-1H-pyrazole-4-carbonitrile 
• 81154-12-3 (5Z)-5-(2-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 

Relevant academic research and scientific papers

Zn@ZIF-67 as Catalysts for the Knoevenagel Condensation of Aldehyde Derivatives with Malononitrile

Abstract: Three different bimetallic zinc-cobalt zeolitic imidazolate frameworks (ZIFs) were successfully synthesized at room temperature in water through a green and simple procedure and tested as catalysts for the Knoevenagel condensation reaction betwe

PMDTA-catalyzed multicomponent synthesis and biological activity of 2-amino-4H-chromenes containing a phosphonate or phosphine oxide moiety

A new approach for the preparation of (2-amino-3-cyano-4H-chromen-4-yl)phosphonate derivatives is described. The multicomponent reaction of salicylaldehydes, malononitrile and dialkyl phosphites catalyzed by pentamethyldiethylenetriamine (PMDTA) provided

Effect of supramolecular polymeric aggregation in room temperature ionic liquids (RTILs) on catalytic activity in the synthesis of 4H-chromene derivatives and Knoevenagel condensation

RTILs exhibit supramolecular self-assembled polymeric aggregation due to noncovalent interactions. The influence of the aggregation behaviour of RTILs on catalytic activity is evident but still poorly understood. The present work focuses on establishing a

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Knoevenagel condensation in aqueous media promoted by 2,2′-bipyridinium dihydrogen phosphate as a green efficient catalyst

A 2,2′-Bipyridine-based ionic compound named 2,2′-bipyridinium dihydrogen phosphate was synthesized by addition of phosphoric acid to a solution of 2,2′-Bipyridine in dichloromethane. After the characterization using FT-IR, mass, 1H, 13C and 31P NMR techniques, it was used as a Bronsted dicationic acidic catalyst for the promotion of the synthesis of 2-arylidene malononitrile and 5-arylidene barbituric acid derivatives via Knoevenagel condensation reaction in water. Some of the advantages of this method are the utilization of an easy preparable, cost-effective and eco-friendly organic salt as a catalyst within high rates and yields of the reactions, simple and quick work-up and acceptable reusability of the catalyst.

Two Cu(II) coordination polymers: Heterogeneous catalytic Knoevenagel condensation reaction and treatment activity on atherosclerosis via regulating the expression of the COX-2 in vascular endothelial cells

By altering auxiliary nitrogen-donor ligands, two novel coordination polymers (CPs) containing Cu(II) formulated as [Cu2.5(L)(trz)2(H2O)2]·2H2O (1) (Htrz = 1,2,4-triazole and H3L = 5-(4-car

Three Resorcin[4]arene-Based Two-Dimensional Zn(II) Supramolecular Isomers Synthesized via a Structure-Directing Strategy for Knoevenagel Condensation

Herein, in the presence of three structure-directing agents (SDAs), a family of imidazole-functionalized resorcin[4]arene-based coordination polymers (CPs), [Zn(TIC4R)(HCOO)]·HCOO·0.5DMF·1.5H2O (1), [Zn(TIC4R)(CN)]·HCOO·DMF·2.5H2O (2), and [Zn(TIC4R)(H2O)

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

Potassium Natural Asphalt Sulfonate (K-NAS): Synthesis and characterization as a new recyclable solid basic nanocatalyst and its application in the formation of carbon–carbon bonds

In this research, we synthesized and characterized a new heterogeneous basic nanocatalyst and its catalytic application was studied in the Claisen-Schmidt and Knoevenagel condensations. In order to prepare this nanocatalyst, first, the Iranian natural asphalt was sulfonated with the concentrated sulfuric acid and then, converted to the potassium natural asphalt sulfonate (K-NAS). In order to characterization of the nanocatalyst, used of FT-IR spectroscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP) and thermogravimetric analysis (TGA) techniques. This new basic heterogeneous nanocatalyst have advantages such as being eco-friendly, huge specific surface area, high reactivity and recyclability.

Reaction kinetics investigation of Malononitrile with substituted benzaldehydes in aqueous solutions of ethaline as deep eutectic solvent

Due to increasing demands for ecofriendly processes within the framework of green chemistry, and having shown substantial properties, especially in terms of toxicity, biodegradability, cost, and ease of preparation under ambient conditions, deep eutectic