69682-13-9

Usage

Uses

Used in Pharmaceutical Industry:
4-(tert-Butyl)piperidine hydrochloride is used as a building block for the synthesis of various pharmaceutical drugs due to its versatile chemical properties and stability. It contributes to the development of new medications by providing a structural foundation for drug molecules.
Used in Organic Chemistry:
4-(tert-Butyl)piperidine hydrochloride is used as a reagent in organic chemistry for various reactions, including the synthesis of complex organic compounds. Its unique structure allows it to participate in a range of chemical transformations, facilitating the creation of diverse chemical products.
Used as a Precursor:
4-(tert-Butyl)piperidine hydrochloride is used as a precursor for the preparation of other chemical compounds, enabling the production of a wide array of substances with specific applications across different industries. Its role as a precursor highlights its importance in the synthesis of specialized chemicals.

InChI:InChI=1/C9H19N.ClH/c1-9(2,3)8-4-6-10-7-5-8;/h8,10H,4-7H2,1-3H3;1H

Upstream product

• 65520-02-7 4-(tert-butyl)pyridin-1-ium chloride 
• 3978-81-2 4-tert-butylpyridine 

Downstream Products

• 1448682-53-8 N-[(1S)-1-[4-[(4-tert-butylpiperidin-1-yl)methyl]phenyl]-2,2,2-trifluoroethyl]methanesulfonamide hydrochloride 
• 1448682-55-0 N-[(1S)-1-{4-[(4-tert-butylpiperidin-1-yl)methyl]phenyl}-2,2,2-trifluoroethyl]methanesulfonamide 
• 1882-42-4 4-tert-butylpiperidine 
• 787-50-8 N-benzoyl-4-tert-butylpiperidine 

Relevant academic research and scientific papers

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.

Determination of the configuration in six-membered saturated heterocycles (N, P, S, Se) and their oxidation products using experimental and calculated NMR chemical shifts

The six-membered saturated heterocycles - 4-tert-butyl-1-methylpiperidine, 4-tert-butyl-1-methylphosphine, 4-tert-butyl-tetrahydro-2H-thiopyran, and 4-tert-butyl-tetrahydro-2H-selenopyran - were prepared as suitable model compounds with well-defined geometry for an NMR study of their oxidation products. The corresponding epimeric N-oxides, phosphinoxides, sulfoxides, and selenoxides were obtained by standard chemical preparation and also by in situ oxidation with meta-chloroperbenzoic acid directly in the NMR tube. The experimental 1H and 13C chemical shifts were compared with corresponding calculated data obtained by GIAO approach with DFT, MP2, and HF methods and various basis sets. The correlation of experimental versus calculated data showed the possibility to determine the stereochemistry of the epimeric oxidation products using fast DFT B3LYP/6-31G* method for both geometry optimization and NMR chemical shifts calculation.

PHENYL METHANESULFONAMIDE DERIVATIVES USEFUL AS MGAT - 2 INHIBITORS

The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.