69700-17-0

Upstream product

• 23428-77-5 1‐(3‐(benzyloxy)‐4‐methoxyphenyl)ethanone 

Downstream Products

• 119038-95-8 3-(3-benzyloxy-4-methoxyphenyl)-2H-1-benzopyran 
• 73053-65-3 (+/-)-trans-1-(3-benzyloxy-4-methoxyphenacyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester 
• 115075-63-3 (4R,5R)-1-(3-benzyloxy-4-methoxyphenacyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester 
• 73608-93-2 (3R,4S)-(+)-1-(3-benzyloxy-4-methoxyphenacyl)-3-ethyl-4-piperidineacetic acid ethyl ester 
• 471294-74-3 2-[2-(3-benzyloxy-4-methoxy-phenyl)-2-oxo-ethyl]-malonic acid diethyl ester 
• 471294-77-6 2-[2-(3-Benzyloxy-4-methoxy-phenyl)-2-oxo-ethyl]-2-[2-(3,4,5-trimethoxy-phenyl)-acetyl]-malonic acid diethyl ester 
• 471294-80-1 4-(3-benzyloxy-4-methoxy-phenyl)-2-oxo-3-(3,4,5-trimethoxy-phenyl)-cyclopent-3-ene-1,1-dicarboxylic acid diethyl ester 
• 73053-55-1 (+/-)-9-benzyloxy-N-(3-benzyloxy-4-methoxyphenethyl)-3α-ethyl-1,3,4,6,7,11bα-hexahydro-10-methoxy-2H-benzoquinolizine-2β-acetamide 
• 73053-56-2 (+/-)-9-benzyloxy-2β-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3α-ethyl-1,3,4,6,7,11bα-hexahydro-10-methoxy-2H-benzoquinolizine 
• 73053-64-2 (+/-)-trans-9-benzyloxy-2-ethoxycarbonylmethyl-3-ethyl-1,2,3,4,6,7-hexahydro-10-methoxybenzoquinolizinium chloride 
• 73053-67-5 (+/-)-trans-5-ethyl-1-(3-hydroxy-4-methoxyphenethyl)-2-oxo-4-piperidineacetic acid ethyl ester 
• 73053-73-3 (+/-)-trans-1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester 
• 73053-54-0 (+/-)-9-benzyloxy-3α-ethyl-1,3,4,6,7,11bα-hexahydro-10-methoxy-2H-benzoquinolizine-2β-acetic acid 
• 73053-66-4 (+/-)-trans-1-<2-(3-benzyloxy-4-methoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones

A series of 3,4-diaryl-2(5H)-furanone derivatives were synthesized and evaluated for their cytotoxicity in a small panel of cancer cell lines. Four out of 10 compounds in this series, for example 3-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-amino-4-methoxyphenyl)-, and 3-(3,4,5-trimethoxyphenyl)-4-(2-naphthyl)-2(5H)-furanones, were found to have potent cytotoxic activities with ED50values of less than 20 nM in most of the cell lines tested.

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative activity, and N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine (10s) was determined to be the most potent compound. Tubulin polymerization and immunostaining experiments revealed that 10s potently inhibited tubulin polymerization and disrupted tubulin microtubule dynamics in a manner similar to CA-4. Moreover, 10s effectively induced SGC-7901 cell cycle arrest at the G2/M phase in both concentrationand time-dependent manners. The molecular docking results revealed that 10s could bind to the colchicine binding site of tubulin.

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.