69703-21-5Relevant academic research and scientific papers
Imidazole-containing condensed tricyclic compound and application thereof
-
Paragraph 0236, (2018/03/01)
The invention discloses an imidazole-containing condensed tricyclic compound adopting the structure as shown in the formula (I) or pharmaceutically acceptable salts, stereisomers or prodrug molecules thereof. The imidazole-containing condensed tricyclic compound has the IDO1 activity regulation function, can enhance T-cell activation through blocking immune checkpoints IDO1, is used for treating IDO1-mediated immunosuppression, and therefore, can become an effective medicine for treating malignant tumors. When used together with checkpoint protein anti-body drugs or other anti-cancer drugs, the imidazole-containing condensed tricyclic compound can enhance the anti-cancer effect. Meanwhile, the imidazole-containing condensed tricyclic compound has the potential of effectively treating IDO1 abnormity related immunosuppressive diseases and has a high application value.
BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065
-
Page/Page column 61, (2009/05/28)
The invention provides compounds of formula wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1
BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066
-
Page/Page column 127, (2009/06/27)
The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.
Solid phase synthesis of 2-substituted benzofurans via the palladium-catalysed heteroannulation of acetylenes
Fancelli, Daniele,Fagnola, Maria Chiara,Severino, Dino,Bedeschi, Angelo
, p. 2311 - 2314 (2007/10/03)
The copper/palladium-promoted heterannulation of terminal acetylenic compounds in the presence of resin bound ortho-hydroxy aryl iodides is described. The process produces 2-substituted benzofuran derivatives in good yield and high purity.
