69705-29-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-iodo-6-methylaniline 95+% is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various drugs and medications.
Used in Pesticide Production:
In the agricultural sector, 4-Chloro-2-iodo-6-methylaniline 95+% is utilized as a component in the production of pesticides, playing a role in creating effective and targeted pest control solutions.
Used in Dye Manufacturing:
4-Chloro-2-iodo-6-methylaniline 95+% is also used in the manufacturing of dyes, where its unique properties contribute to the creation of a diverse range of colorants for various applications.
Used in Organic Synthesis:
4-Chloro-2-iodo-6-methylaniline 95+% is employed as a building block in organic synthesis, enabling the production of other organic compounds for research and commercial purposes.
Used in Research Processes:
Due to its high purity level, 4-Chloro-2-iodo-6-methylaniline makes a valuable and reliable chemical for use in research processes, facilitating the discovery and development of new chemical entities and their applications.

Upstream product

• 95-69-2 4-chloro-2-methylbenzeneamine 

Downstream Products

• 939990-03-1 2-amino-5-chloro-3-methylbenzonitrile 
• 644961-69-3 4-chloro-2-methoxy-6-methylphenylamine 

Relevant academic research and scientific papers

C?N Axial Chiral Hypervalent Iodine Reagents: Catalytic Stereoselective α-Oxytosylation of Ketones

A simple synthesis of a library of novel C?N axially chiral iodoarenes is achieved in a three-step synthesis from commercially available aniline derivatives. C?N axial chiral iodine reagents are rarely investigated in the hypervalent iodine arena. The potential of the novel chiral iodoarenes as organocatalysts for stereoselective oxidative transformations is assessed using the well explored, but challenging stereoselective α-oxytosylation of ketones. All investigated reagents catalyse the stereoselective oxidation of propiophenone to the corresponding chiral α-oxytosylated products with good stereochemical control. Using the optimised reaction conditions a wide range of products was obtained in generally good to excellent yields and with good enantioselectivities.

Isothiourea-Catalyzed Atroposelective N-Acylation of Sulfonamides

We report herein an atroposelective N-acylation of sulfonamides using a commercially available isothiourea catalyst, (S)-HBTM, with a simple procedure. The N-sulfonyl anilide products can be obtained in good to high enantiopurity, which represents a new axially chiral scaffold. The application of the product as a chiral iodine catalyst is also demonstrated for the asymmetric α-oxytosylation of propiophenone.

Revisiting the Gold-Catalyzed Dimerization of 2-Ethynylanilines: A Room-Temperature and Silver-Free Protocol for the Synthesis of Multifunctional Quinolines

A room temperature and silver-free protocol for the formation of quinolines from 2-ethynylanilines through a dimerization event was achieved using a dinuclear gold catalyst, Au2(BIPHEP)(NTf2)2. The reaction is inherently modular, allowing for the incorporation of peripheral substituents at any site of the quinoline product. The reaction is readily applied to other heterocyles also as exemplified by the preparation of naphthyridines. Competition reactions to determine the reactivity of dissimilar alkynes demonstrated that the product ratio of dimerization vs intermolecular addition is rather dependent on the electronic nature of aryl substituent on the alkynes. However, control experiments with substrates possessing internal alkynes resulted in cycloisomerization instead of expected dimerization, which is indicative of possible steric influence of the alkyne terminus in the reaction outcome.

BENZAMIDE DERIVATIVE

The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

QUINAZOLINEDIONE DERIVATIVE

The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

NEW ARYL-QUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I), wherein R1, R2, R3, R4 R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds.

ARYL-QUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.

A mild and convenient synthesis of 1,2,3-triiodoarenes via consecutive iodination/diazotization/iodination strategy

A mild and convenient synthesis of 1,2,3-triiodoarenes has been developed. This method consists of two steps which can be performed on multigram scale with moderate to excellent yields. This report discloses a practical synthesis of 1,2,3-triiodoarenes and 1,2,3-trihaloarenes that is general in scope, operationally simple, scalable, and is easy to workup and to purify. We also report the first regioselective transmetalation reaction of 1,2,3-triiodoarenes to provide ortho-diiodoaryl derivatives, which are useful building blocks and indeed are hard to make by other means. CSIRO 2013.

2-AMINO PYRIMIDINE COMPOUNDS AS POTENT HSP-90 INHIBITORS

The present invention is directed to compounds of formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

Palladium-catalyzed synthesis of 5- and 5,7-substituted indole derivatives

The reaction of IPy2BF4 with anilines give the corresponding 2- iodoanilines regioselectively in high yields. N-Allyl-2-iodoanilines undergo cyclization to give 5- and 5,7-substituted indole derivatives in the presence of palladium catalysts and bases. The procedure do not require protective groups on nitrogen.