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A straightforward synthesis of 4-substituted 3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides
Agejas,Garcia-Navio,Lamas
, p. 9819 - 9823 (2000)
4-Substituted 3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides 11 have been efficiently prepared in two steps from the suphamide 9 by condensation of anion II, derived from 9 by metal-halogen exchange, with aromatic and aliphatic aldehydes and cyclodehydration of the so-formed alcohols 10 under acidic conditions. (C) 2000 Elsevier Science Ltd.
