69718-72-5

Usage

Uses

Used in Medicinal Chemistry:
10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE is used as a chemical intermediate for the development of antidepressant and antipsychotic drugs due to its tricyclic structure, which is commonly found in such pharmaceuticals.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, 10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE is used as a reactive intermediate for the synthesis of new molecules, taking advantage of the tosylate group's reactivity to facilitate various chemical reactions and transformations.
Used in Pharmaceutical Industry:
10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE is used as a building block in the pharmaceutical industry for the design and synthesis of novel therapeutic agents, leveraging its tricyclic framework and tosylate functionality to create innovative drug candidates.
Used in Organic Synthesis Research:
In the realm of organic synthesis research, 10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE serves as a model compound for studying the reactivity and functionalization of tricyclic systems, as well as the role of the tosylate group in various synthetic transformations.

InChI:InChI=1/C11H13N/c1-2-4-11-9-5-8(6-12-7-9)10(11)3-1/h1-4,8-9,12H,5-7H2

Upstream product

• 615-13-4 2-indanone 
• 39094-23-0 1,3-dibromo-indan-2-one 

Downstream Products

• 230615-51-7 1-(10-aza-tricyclo[6.3.1.0^2,7]dodeca-2⁽⁷⁾,3,5-trien-10-yl)-2,2,2-trifluoro-ethanone 
• 230615-52-8 2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride 

Relevant academic research and scientific papers

Preparation method of varenicline key intermediate

The invention discloses a preparation method of a varenicline key intermediate. A target compound is prepared from indanone by the six steps of halogenation, cyanidation, hydrolysis, closed-loop reaction, reduction and hydrochloride formation. The preparation method has the advantages of easy availability of raw materials, mild reaction conditions, simple process, high yield, low cost, low environmental pollution and good utilization value in industrial production.

Synthesis of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine via oxidative cleavage and reductive amination strategies

Preparations of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine (5) from benzonorbornadiene (1) by oxidative cleavage and reductive amination sequences were investigated. Osmium-mediated dihydroxylation of 1 followed by NaIO 4 cleavage, reductive amination and debenzylation provides 5 in 64-73% yield overall in three operations. A tandem ozonolysis-reductive amination procedure gives 5 as the tosylate salt from benzonorbornadiene with no isolation of intermediates in 28% yield.

Nicontinic acetylcholine receptor antagonists in the treatment of restless legs syndrome

This invention relates to the use of nicotinic acetylcholine receptor agonists for the treatment of restless legs syndrome (RLS). The invention further relates to the use of a nicotinic acetylcholine receptor agonist in the manufacture of a medicament for the treatment of RLS. The present invention also relates to a pharmaceutical composition for the treatment of RLS containing a nicotinic acetylcholine receptor agonist.