69719-54-6

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 61812-54-2 4,4'-(oxybis(methylene))bis(fluorobenzene) 

Relevant academic research and scientific papers

Synthesis method of dibenzyl sulfide

As an important organic intermediate and a synthesis reagent, an organic sulfur compound also has unique pharmacological effects of resisting tumors, inflammation, bacteria and oxidation, preventing aging, preventing and treating cardiovascular diseases and the like. The patent develops a method for synthesizing dibenzyl sulfide without metal catalysis. In an acetonitrile solution, benzyl trifluoromethanesulfonic acid quaternary ammonium salt and sodium sulfide nonahydrate are used to synthesize dibenzyl sulfide in a wide substrate range with good to excellent yield through breakage of a carbon-nitrogen bond and generation of a carbon-sulfur bond. The method has the advantages of mild reaction conditions, simple operation, no metal, high yield, wide substrate applicability and the like.

Indium-catalyzed direct conversion of dibenzyl ethers to dibenzyl sulfides using elemental sulfur and a hydrosilane and its application to the preparation of benzyl selenides

Described herein is a catalytic system composed of an indium(III) compound, a hydrosilane and an easily handled form of elemental sulfur (S8) that effectively and directly catalyzes the sulfidation of dibenzyl ethers to produce dibenzyl sulfides. This system could also be applied to selenium in a straightforward conversion to dibenzyl selenides.

Indium-catalyzed direct preparation of dibenzyl sulfides from benzyl alcohols and elemental sulfur with a hydrosilane and its application to the preparation of dibenzyl selenide

We describe how a reducing system composed of InI3 and a hydrosilane efficiently and directly introduce elemental sulfur into the structure of dibenzyl sulfides via a nucleophilic substitution of benzyl alcohols. Also, we describe the application of this reducing system in the direct preparation of a dibenzyl selenide derivative with selenium.

Indium(III)-catalyzed reductive one-pot synthesis of thioethers from aromatic aldehydes and elemental sulfur

Described herein is that a combination of InI3 and 1,1,3,3-tetramethyldisiloxane (TMDS) effectively promotes the reductive thioetherification from aromatic aldehydes with elemental sulfur (S8).

Azaindole derivatives useful as cholesterol biosynthesis inhibitors

Compounds of the formula I: STR1 wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom; R1 is C1-6 primary alkyl (free of asymmetric carbon atoms), or isopropyl; R2 is substituted or unsubstituted phenyl, primary or secondary C1-6 alkyl (free of asymmetric carbons), C3-6 cycloalkyl or phenalkyl as defined in the Specification STR2 in which R8 is hydrogen, R9 or M, wherein R9 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation; are obtained by multi-step processes and are useful as cholesterol biosynthesis inhibitors. 3