69720-51-0Relevant articles and documents
Oxamates derived from 5-aminopyrazoles
Peet
, p. 193 - 197 (2007/10/02)
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Reactions of 3-Chloro-6-hydrazinopyridazine with Michael-retro-Michael Reagents
Sunder, Shyam,Peet, Norton P.
, p. 1527 - 1529 (2007/10/02)
Although pyrazole formation results from treatment of 3-chloro-6-hydrazinopyridazine (2) with both ethoxymethylenemalononitrile and ethyl (ethoxymethylene)cyanoacetate, 6-chlorotriazolopyridazine (5) was produced (75percent yield) when 2 was treated with diethyl ethoxymethylenemalonate.Treatment of 2 with diethyl acetylmalonate (8) gave both 6-chloro-3-methyltriazolopyridazine (10) and 5-hydroxy-3-methyl-1-(6-chloro-3-pyridazinyl)-1H-pyrazole-4-carboxylic acid ethyl ester (12).Pyrazole 12 was initially isolated as a salt of triazolopyridazine 10.