69720-59-8Relevant academic research and scientific papers
3-(1-Pyrazolyl)-pyridazine derivatives
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, (2008/06/13)
3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, STR1 wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, cyano, carboxyl, carbamoyl, carbaxoyl or C1-4 alkoxycarbonyl, R3 is hydrogen or chlorine or --NR4 NHR5 or NR6 R7, wherein R4 and R5 are each hydrogen or C1-4 alkyl, wherein R6 and R7 are each hydrogen or C1-5 alkyl, C1-5 hydroxyalkyl, C3-7 cycloalkyl, phenyl or benzyl, or benzyl or phenylethyl substituted with one or two chlorine atoms or methoxy groups, or a furylmethyl, pyridylmethyl, pyrrolidine or piperazine ring, or when R7 is hydrogen, R6 is --(CH2)n --NR4 R5 wherein n is an integer from 1 to 3.
Studies in the field of pyridazine compounds, III (1). Hypotensive 3-(1-pyrazolyl) pyridazine derivatives
Szilagyi,Kasztreiner,Tardos,et al.
, p. 439 - 445 (2007/10/05)
Substituted 3-(1-pyrazolyl)pyridazines were synthesized and their hypotensive activity was evaluated on anaesthetized normotensive cats and awake spontaneously hypertensive rats. Several relations were found between structure and hypotensive activity of the compounds. Some of the active compounds proved to be useful for detailed investigations. Most of the active compounds exerted an influence on prostaglandin metabolism.
