697245-45-7Relevant academic research and scientific papers
Tris-hydroxymethylaminomethane (THAM): A novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles
Pandit, Kapil S.,Chavan, Pramod V.,Desai, Uday V.,Kulkarni, Makarand A.,Wadgaonkar, Prakash P.
, p. 4452 - 4463 (2015)
A simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles using a commercially available, inexpensive, non-toxic, and biodegradable tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. Ambient reaction conditions, wide scope, avoidance of conventional isolation as well as purification techniques and the reusability of the catalyst for five consecutive runs have improved the practical utility of this multicomponent reaction protocol manifold.
Nanozeolite clinoptilolite as a highly efficient heterogeneous catalyst for the synthesis of various 2-amino-4H-chromene derivatives in aqueous media
Baghbanian, Seyed Meysam,Rezaei, Niloufar,Tashakkorian, Hamed
, p. 3446 - 3458 (2013/12/04)
The preparation of pharmaceutically active 2-amino-4H-chromene derivatives has been achieved using a nano powder of natural clinoptilolite (CP) zeolite. A wide range of these worthy structures having diverse substituents on the 4H-chromene ring were effic
Pyrano [3,2-C] Pyridones and Related Heterocyclic Compounds as Pharmaceutical Agents for Treating Disorders Responsive to Apoptosis, Antiproliferation or Vascular Disruption, and the Use Thereof
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Page/Page column 2-3, (2009/10/06)
A pharmaceutical composition comprising a pharmaceutically acceptable excipient or carrier and a compound Formula I: or a pharmaceutically acceptable salt or prodrug thereof.
Structural simplification of bioactive natural products with multicomponent synthesis. 2. Antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones
Magedov, Igor V.,Manpadi, Madhuri,Ogasawara, Marcia A.,Dhawan, Adriana S.,Rogelj, Snezna,Van Slambrouck, Severine,Steelant, Wim F. A.,Evdokimov, Nikolai M.,Uglinskii, Pavel Y.,Elias, Ecrik M.,Knee, Erica J.,Tongwa, Paul,Antipin, Mikhail Yu.,Kornienko, Alexander
, p. 2561 - 2570 (2008/12/22)
Pyrano[3,2-c]pyridone and pyrano[3,2-c]quinolone structural motifs are commonly found in alkaloids manifesting diverse biological activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent sy
