697246-11-0

Basic information

• Product Name: N-(4-acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide
• Synonyms: N-(4-acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide
• CAS NO: 697246-11-0
• Molecular Formula: C₂₀H₂₀N₄O₂S
• Molecular Weight: 380.4634
• Mol File: 697246-11-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide(697246-11-0)
• EPA Substance Registry System: N-(4-acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide(697246-11-0)

Safety Data

• Hazardous Substances Data: 697246-11-0(Hazardous Substances Data)

Upstream product

• 923558-12-7 C₂₀H₂₀N₄O₂S 

Relevant articles and documents

Synthesis of thieno[2,3-b][1,6]naphthyridines and pyrimido[4',5':4,5] thieno[2,3-b][1,6]naphthyridines

3-Cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridine-2(1H)-thione (3a) and 3-cyano-6-methyl-4-(2'-thienyl)-5,6,7,8-tetrahydro[1,6]naphthyridine-2(1H)- thione (3b) were reacted with a-halo compounds to give the intermediates 4a-j which upon refluxing in ethanolic sodium ethoxide afforded the thieno[2,3-b][1,6]naphthyridine derivatives 5a-l. Further annellation of pyridine and pyrimidine rings to the remaining free bond of the fused thiophene ring was achieved, providing tetrahydro-pyrido[2',3':4,5]- and -pyrimido[4',5':4,5]-thieno[2,3-b][1,6]naphthyridines. Some of the synthesised compounds were screened against different strains of bacteria.