697266-20-9

Basic information

• Product Name: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester
• Synonyms: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester
• CAS NO: 697266-20-9
• Molecular Weight: 727.004
• Mol File: 697266-20-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester(697266-20-9)
• EPA Substance Registry System: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester(697266-20-9)

Safety Data

• Hazardous Substances Data: 697266-20-9(Hazardous Substances Data)

Upstream product

• 697266-17-4 6-(2-aminoethyl)-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester pivalate salt 
• 125971-96-2 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide 

Downstream Products

• 134523-03-8 lipitor 

Relevant articles and documents

SYNTHESIS OF 3,5-DIHYDROXY-7-PYRROL-1-YL HEPTANOIC ACIDS

Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihydroxy heptanoic acid esters undergo Paal Knorr reaction with 1,4-diketones to give valuable silylether-diprotected 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acid ester intermediates for preparing atorvastatin. The Paal Knorr reaction of ketal-proctected 7-amino-3R, 5R-dihydroxy heptanoic acid esters with 4-fluoro-α-(2-methyl-1-oxopropyl-γ-oxo-N,β-diphenylbenzenebutanamide occurs in high yield with few side products when it is conducted in a low boiling point ether.