697288-08-7Relevant academic research and scientific papers
Investigation of intramolecular Pauson-Khand reaction of 2-aryl-1,6- and 1-methyl-1,7-enynes (exo-olefins) and 1-phenyl-1-octen-7-yne (endoolefin)
Ishizaki, Miyuki,Satoh, Hiroshi,Hoshino, Osamu,Nishitani, Kiyoshi,Hara, Hiroshi
, p. 827 - 844 (2004)
The intramolecular Pauson-Khand reaction of various 2-aryl-1-hepten-6-ynes and its aza-derivatives (exo-olefins) efficiently produced arylbicyclo[3.3.0]octenones and azaoctenone bearing quaternary carbon centers at angular positions in good yields. Although a similar reaction of 2-phenyl-1-octen-7-yne (exo-olefin), which is a homologue of 2-phenyl-1-hepten-6-yne, did not take place, the reaction of the methyl derivatives smoothly proceeded. However, the reaction of regioisomeric 1-phenyl-1-octen-7-yne (endo-olefin) afforded the desired product in moderate yields.
