697299-87-9

Usage

Uses

Used in Pesticide Industry:
Tert-butyl (4-bromothiazol-2-yl)methylcarbamate is utilized as an insecticide for its ability to disrupt the nervous system of insects, leading to their death. The stability and resistance to degradation provided by the tert-butyl group make it an effective and long-lasting agent in controlling insect populations.
Used in Insecticide Formulations:
In the formulation of insecticides, tert-butyl (4-bromothiazol-2-yl)methylcarbamate serves as an active ingredient, contributing to the control of various insect pests that can damage crops and transmit diseases. Its long-lasting effect is particularly beneficial in agricultural settings where persistent protection against insect infestations is required.
However, it is important to note that the use of tert-butyl (4-bromothiazol-2-yl)methylcarbamate has raised environmental and health concerns due to its potential impacts. As a result, regulations have been implemented to govern its application, and caution is advised in handling tert-butyl (4-bromothiazol-2-yl)methylcarbamate to prevent irritation to the skin, eyes, and respiratory system in humans.

InChI:InChI=1/C9H13BrN2O2S/c1-9(2,3)14-8(13)12(4)7-11-6(10)5-15-7/h5H,1-4H3

Upstream product

• 697299-86-8 1-(4-bromo-1,3-thiazol-2-yl)methanamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4248-19-5 tert-butyl carbazate 

Relevant academic research and scientific papers

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth

The lysyl oxidase (LOX) family of extracellular proteins plays a vital role in catalyzing the formation of cross-links in fibrillar elastin and collagens leading to extracellular matrix (ECM) stabilization. These enzymes have also been implicated in tumor progression and metastatic disease and have thus become an attractive therapeutic target for many types of invasive cancers. Following our recently published work on the discovery of aminomethylenethiophenes (AMTs) as potent, orally bioavailable LOX/LOXL2 inhibitors, we report herein the discovery of a series of dual LOX/LOXL2 inhibitors, as well as a subseries of LOXL2-selective inhibitors, bearing an aminomethylenethiazole (AMTz) scaffold. Incorporation of a thiazole core leads to improved potency toward LOXL2 inhibition via an irreversible binding mode of inhibition. SAR studies have enabled the discovery of a predictive 3DQSAR model. Lead AMTz inhibitors exhibit improved pharmacokinetic properties and excellent antitumor efficacy, with significantly reduced tumor growth in a spontaneous breast cancer genetically engineered mouse model.

Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors

Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.