69730-17-2Relevant academic research and scientific papers
The reactivity of 4'-substituted spiro[isoindole-1,3'-pyrazoles] derivatives: Substitution/elimination reactions and access to biaryl derivatives
Maggio, Benedetta,Fontana, Gianfranco,Raimondi, Maria Valeria,Raffa, Demetrio,Plescia, Fabiana,Ingarra, Angela Maria,Daidone, Giuseppe
, p. 241 - 254 (2017/03/27)
This paper describes aspects of the chemistry of 4'-substituted spiro[isoindole-1,3'-pyrazoles]. These compounds underwent substitution and/or elimination reactions to afford some new spiro- as well as biaryl derivatives of potential pharmaceutical releva
Studies on the Synthesis of Heterocyclic Compounds. Part IV. Further Investigation of the Pschorr Reaction with Some Pyrazole Derivatives
Daidone, Giuseppe,Plescia, Salvatore,Fabra, Jole
, p. 1409 - 1411 (2007/10/02)
Thermal decomposition of the diazonium sulfate derived from N-methyl-(1-phenyl-3-methylpyrazol-5-yl)-2-aminobenzamide afforded products formulated as 1-phenyl-3-methylbenzopyranopyrazol-5-one (yield 10percent), 1,4-dimethyl-3-phenylpyrazoloisoquinolin-5-one (yield 10percent), N-methyl-(1-phenyl-3-methyl-pyrazol-5-yl)-2-hydroxybenzamide (yield 8percent) and 4'-hydroxy-2,3'-dimethyl-1'-phenylspiro-pyrazolin>-3-one (yield 20percent).Decomposition of the diazonium sulfate derived from N-methyl-(1,3-diphenyl-pyrazol-5-yl)-2-aminobenzamide gave products formulated as 7,9-dimethyldibenzopyrazolo-diazocin-10-(9H)one (yield 8percent), 4-methyl-1,3-diphenylpyrazoloisoquinoline-5-one (yield 7percent) and 4'-hydroxy-2-methyl-1',3'-diphenylspiropyrazolin>-3-one (yield 10percent).The spiro compounds 6a,b underwent thermal and acid-catalysed conversion into the hitherto unknown 2-benzopyranopyrazole ring system 7a,b in good yield.Analytical and spectral data are presented which supported the structures proposed.
