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697300-73-5

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697300-73-5 Usage

Description

3-Bromo-5-iodopyridin-2-amine is a specialized chemical compound with a molecular formula of C5H3BrIN2 and a molecular weight of 282.90 g/mol. It is characterized by the presence of functional groups such as bromo and iodo substituents and an amino group, which make it valuable for various chemical reactions. 3-Bromo-5-iodopyridin-2-amine is primarily used in sophisticated research fields, including organic synthesis and drug discovery. Due to its potential for eye, skin, and respiratory irritation, it must be handled with care, and safety measures as recommended by Material Safety Data Sheets (MSDS) should be followed.

Uses

Used in Organic Synthesis:
3-Bromo-5-iodopyridin-2-amine is used as a key intermediate in the synthesis of complex organic molecules. Its functional groups facilitate various chemical reactions, making it a versatile building block for the creation of new compounds.
Used in Drug Discovery:
3-Bromo-5-iodopyridin-2-amine is employed as a potential candidate in drug discovery, particularly for the development of novel therapeutic agents. Its unique structure and functional groups allow for the exploration of its potential biological activities and interactions with target molecules in the pharmaceutical industry.
Used in Research Applications:
3-Bromo-5-iodopyridin-2-amine is used as a research tool in academic and industrial laboratories. Its properties and reactivity are studied to gain insights into chemical reactions and to develop new methodologies for the synthesis of related compounds.
Used in Chemical Reactions:
3-Bromo-5-iodopyridin-2-amine is used as a reactant in various chemical reactions, such as coupling, substitution, and reduction processes. Its functional groups enable it to participate in a wide range of transformations, making it a valuable component in the synthesis of diverse chemical products.

Check Digit Verification of cas no

The CAS Registry Mumber 697300-73-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,3,0 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 697300-73:
(8*6)+(7*9)+(6*7)+(5*3)+(4*0)+(3*0)+(2*7)+(1*3)=185
185 % 10 = 5
So 697300-73-5 is a valid CAS Registry Number.

697300-73-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Bromo-5-iodopyridin-2-amine

1.2 Other means of identification

Product number -
Other names 3-bromo-5-iodopyridin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:697300-73-5 SDS

697300-73-5Relevant articles and documents

MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF

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Paragraph 0201-0203, (2021/07/08)

The present invention relates to multi-substituted pyridone derivatives and therapeutic use thereof. In particular, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, as well as use thereof as a tyrosine kinase inhibitor, in particular, use thereof in treating a disease associated with tyrosine kinase activity. Each substituent in the formula (I) is defined as in the specification.

TRIAZOLOPYRIDINE COMPOUNDS

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Page/Page column 32, (2012/12/14)

The present invention relates to the use of novel triazolopyridine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography

Zhang, Yi,Pavlova, Olga A.,Chefer, Svetlana I.,Hall, Andrew W.,Kurian, Varughese,Brown, LaVerne L.,Kimes, Alane S.,Mukhin, Alexey G.,Horti, Andrew G.

, p. 2453 - 2465 (2007/10/03)

Potential positron emission tomography (PET) ligands with low picomolar affinity at the nicotinic acetylcholine receptor (nAChR) and with lipophilicity (log D) ranging from - 1.6 to +1.5 have been synthesized. Most members of the series, which are derivatives of 5-substituted-6-halogeno-A-85380, exhibited a higher binding affinity at α4β2-nAChRs than epibatidine. An analysis, by molecular modeling, revealed an important role of the orientation of the additional heterocyclic ring on the binding affinity of the ligands with nAChRs. The existing nicotinic pharmacophore models do not accommodate this finding. Two compounds of the series, 6-[18F]fluoro-5-(pyridin-3-yl)-A-85380 ([18F]31) and 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-[ 18F]fluoropyridin-5-yl)pyridine) ([18F]35), were radiolabeled with 18F. Comparison of PET data for [18F]31 and 2-[18F]FA shows the influence of lipophilicity on the binding potential. Our recent PET studies with [18F]35 demonstrated that its binding potential values in Rhesus monkey brain were ca. 2.5 times those of 2-[18F]FA. Therefore, [18F]35 and several other members of the series, when radiolabeled, will be suitable for quantitative imaging of extrathalamic nAChRs.

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