69737-12-8Relevant articles and documents
Action d'organolithiens sur la methyl-2 quinoxaline. Etude de la reactivite des adduits
Mettey, Yvette,Vierfond, Jean-Michel,Thal, Claude,Miocque, Marcel
, p. 133 - 137 (2007/10/02)
The action of organolithium reagents such as phenyllithium or n-butyllithium on 2-methylquinoxaline gave lithiation of the methyl group which upon reaction with electrophiles produce side chain alkenyl derivatives.On the other hand organolithium reagents react with the quinoxaline azomethine bond to give 1-lithio-2-alkyl(or aryl)-3-methylquinoxalines which can be further lithiated on the methyl group to give 2-alkyl(or aryl)-3-alkenylquinoxaline derivatives.The adducts can be condensed with electrophiles such as benzonitrile or methyl benzoate but only methyl benzoate leads to N condensed derivatives.Furthermore substituted 1,2,3,4-tetraquinoxalines are available via the above lithio intermediates.