6974-47-6Relevant articles and documents
An efficient Pd@Pro-GO heterogeneous catalyst for the α, β-dehydrogenation of saturated aldehyde and ketones
Chang, Yi-Yuan,Hao, Yue,Pan, Gao-Fei,Wang, Yi-Chen,Wang, Zhe,Xing, Rui-Guang
supporting information, (2021/12/30)
An Efficient Pd@Pro-GO heterogeneous catalyst was developed that can promote the α, β-dehydrogenation of saturated aldehyde and ketones in the yield of 73% ? 92% at mild conditions without extra oxidants and additives. Pd@Pro-GO heterogeneous catalyst was synthesized via two steps: firstly, the Pro-GO was obtained by the esterification reaction between graphene oxide (GO) and N-(tert-Butoxycarbonyl)-L-proline (Boc-Pro-OH), followed by removing the protection group tert-Butoxycarbonyl (Boc), which endowed the proline-functionalized GO with both the lewis acid site (COOH) and the bronsted base site (NH), besides, the pyrrolidine of proline also can form imine with aldehydes to activate these substrates; Second, palladium was dispersed on the proline-functionalized GO (Pro-GO) to obtained heterogeneous catalyst Pd@Pro-GO. Mechanistic studies have shown that the Pd@Pro-GO-catalyzed α,β-dehydrogenation of saturated aldehyde and ketones was realized by an improved heterogeneously catalyzed Saegusa oxidation reaction. Based on the obove characteristics, the Pd@Pro-GO will be widely used in the transition metal catalytic field.
The present invention relates to a new process for the preparation of heliotropine
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Page/Page column 4; 5, (2017/02/17)
The invention relates to a method for preparing helional and discloses a method which comprises steps of carrying out Claisen-Schmidt condensation reaction between heliotropin serving as a raw material and propionaldehyde under the catalysis of strong-basicity ion exchange resin, and further performing catalytic hydrogenation so as to obtain the target product. The method is characterized in that the strong-basicity ion exchange resin is used to replace other strong bases for catalyzing Claisen-Schmidt condensation reaction, the reaction yield is greatly improved, disproportionation reaction which can cause relevant impurities is avoided, and the purification is easy. The method is a route which is high in yield, low in cost, safe and applicable for industrial synthesis.
An organocatalytic asymmetric nazarov cyclization
Basak, Ashok K.,Shimada, Naoyuki,Bow, William F.,Vicic, David A.,Tius, Marcus A.
supporting information; experimental part, p. 8266 - 8267 (2010/08/04)
An organocatalytic asymmetric Nazarov cyclization of diketoesters that proceeds by means of a dual activation mechanism has been developed. Screening of a number of catalysts led to a new thiourea that incorporates a primary amino group. The method gives rise to cyclic products with two adjacent quaternary asymmetric carbon atoms, one of which is an all-carbon stereocenter, with complete or nearly complete diastereoselectivity and in high or very high enantiomeric excess. A brief and very convenient synthesis of the acyclic diketoester starting materials through nucleophilic addition to a ketene is also described.