69746-29-8Relevant academic research and scientific papers
TETRAZOLES. VIII. KINETICS AND RATIO OF THE REACTION PRODUCTS IN THE ALKYLATION OF THE SALTS OF SUBSTITUTED 5-PHENYLTETRAZOLES BY DIMETHYL SULFATE IN ACETONITRILE
Ostrovskii, V. A.,Shirobokov, I. Yu.,Koldobskii, G. I.
, p. 131 - 135 (2007/10/02)
The kinetics and the ratio of the reaction products were investigated for the alkylation of potassium salts of a series of substituted 5-phenyltetrazoles by dimethyl sulfate in acetonitrile.It was shown that with the salt at a concentration of less than 10-3M the corresponding tetrazolate ion enters into reaction with dimethyl sulfate.Electron-withdrawing substituents in the benzene ring reduce the rate of the alkylation reaction and help to increase the proportion of the N2 isomer in the reaction products.The rate constants for the reaction of substituted 5-phenyltetrazoles with dimethyl sulfate and the ratios of the isomeric tetrazoles formed during alkylation correlate with the ? constants of the substituents.
