69746-32-3

Basic information

• Product Name: 1H-Tetrazole,1-methyl-5-(3-nitrophenyl)-
• Synonyms: 1-Methyl-5-(3-nitrophenyl)tetrazole
• CAS NO: 69746-32-3
• Molecular Formula: C8H7 N5 O2
• Molecular Weight: 205.176
• Mol File: 69746-32-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazole,1-methyl-5-(3-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole,1-methyl-5-(3-nitrophenyl)-(69746-32-3)
• EPA Substance Registry System: 1H-Tetrazole,1-methyl-5-(3-nitrophenyl)-(69746-32-3)

Safety Data

• Hazardous Substances Data: 69746-32-3(Hazardous Substances Data)

Usage

General Description

1H-Tetrazole, 1-methyl-5-(3-nitrophenyl)- is a chemical compound with the molecular formula C9H8N6O2. It is a tetrazole derivative with a methyl group and a nitrophenyl group attached to the tetrazole ring. 1H-Tetrazole,1-methyl-5-(3-nitrophenyl)- is used in the synthesis of pharmaceuticals and agrochemicals due to its ability to act as a building block in organic chemistry reactions. It is also used as a stabilizer for rocket propellants and a precursor in the production of dyes and pigments. Additionally, 1H-Tetrazole, 1-methyl-5-(3-nitrophenyl)- has the potential to exhibit biological activity and could be studied for its potential pharmacological properties.

Upstream product

• 3400-26-8 N-methyl-3-nitro-benzamide 
• 20743-50-4 1-methyl-5-phenyltetrazole 
• 619-24-9 3-nitrobenzonitrile 
• 74-88-4 methyl iodide 
• 121-89-1 3-Nitroacetophenone 
• 78137-21-0 C₇H₄N₅O₂^(1-)*K⁽¹⁺⁾ 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 120819-56-9 C₉H₁₀N₅O₂⁽¹⁺⁾*CH₃O₄S^(1-) 
• 120819-40-1 C₉H₁₀N₅O₂⁽¹⁺⁾*CH₃O₄S^(1-) 
• 101258-12-2 1-methyl-5-(3-aminophenyl)-tetrazole 
• 382637-78-7 [3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester 

Relevant articles and documents

Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors

β-Lactam antibiotic resistance mediated by metallo-β-lactamases (MBL) has threatened global public health. There are currently no available inhibitors of MBLs for clinical use. We previously reported the ruthenium-catalyzed meta-selective C-H nitration synthesis method, leading to some meta-mercaptopropanamide substituted aryl tetrazoles as new potent MBL inhibitors. Here, we described the structure-activity relationship of meta- and ortho-mercaptopropanamide substituted aryl tetrazoles with clinically relevant MBLs. The resulting most potent compound 13a showed IC50 values of 0.044 μM, 0.396 μM and 0.71 μM against VIM-2, NDM-1 and IMP-1 MBL, respectively. Crystallographic analysis revealed that 13a chelated to active site zinc ions via the thiol group and interacted with the catalytically important residues Asn233 and Tyr67, providing further structural information for the development of thiol based MBL inhibitors. This journal is

ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3, in particular inflammatory or obstructive airway diseases.

SUBSTITUTED SPIRO AZABICYCLICS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of CCR3 of formula (Ia) and (Ib): (I) or pharmaceutically acceptable salt forms thereof, wherein Z, R1, R2, R3, R4, R5, R5', R6, a, b