69746-41-4

Usage

Classification

pyranone antibiotic

Functional groups

chlorobenzoyl, chlorophenyl, hydroxy

Antibacterial activity

exhibits antibacterial activity, particularly against gram-positive bacteria

Potential use

being studied for potential use in treating antibiotic-resistant infections

Inhibitory effect

has an inhibitory effect on bacterial DNA gyrase

Promise

a promising candidate for the development of new antibiotics

Upstream product

• 58303-62-1 5-(4-chlorophenyl)-2,3-dihydrofuran-2,3-dione 
• 2085-31-6 2-diazo-1,3-diphenylpropane-1,3-dione 

Relevant academic research and scientific papers

Investigation of the interaction of 5-aryl-2,3-dihydro-2,3-furandiones with compounds containing C=N and C≡N bonds simultaneously

Aroylketenes, generated by the thermolysis of 5-aryl-2,3-dihydro-2,3- furandiones, react with S-methyl-N-cyano-N′-phenylisothiourea, N-cyano-N′,N′-dimethylformamidine, and N,N-bis(β-cyanoethyl) cyanamide with the formation of 6-aryl-2-[(methylthio)(phenyl

Synthesis of Pyranones by Dimerization of Aroylketenes

Thermolysis of 5-aryl-2,3-dihydrofuran-2,3-diones in the presence of dibenzoyldiazomethane yields 6-aryl-3-aroyl-4-hydroxy-2H-pyran-2-ones and 3-aroyl-4-hydroxy-5,6-diphenyl-2H-pyran-2-ones, as the result of [2+4] cycloaddition of aroylketenes that arise from thermolysis both of the furandiones and of dibenzoyldiazomethane. Thermolysis of 5-aryl-4-methyl-2,3-dihydrofuran-2,3-diones and dibenzoyldiazomethane results in exclusive formation of 6-aryl-3-aroyl-3,5-dimethyl-3,4-dihydro-2H-pyran-2,4-diones.