697795-88-3

Upstream product

• 186581-53-3 diazomethane 
• 104139-75-5 O-(2-O-benzoyl-3-O-benzyl-α-L-idopyranosyl)-(1->4)-1,6-anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranose 
• 55682-57-0 1,6-anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranose 
• 904313-18-4 4,6-di-O-acetyl-2-O-benzoyl-3-O-benzyl-α-L-idopyranosyl-(1->4)-1,6-anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranoside 

Downstream Products

• 904313-19-5 methyl (2-O-benzoyl-3-O-benzyl-4-O-levulinoyl-α-L-idopyranosyl)uronate-(1->4)-1,6-anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranoside 

Relevant academic research and scientific papers

Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors

Two fully protected tetrasaccharides, which represent precursors for the synthesis of the regular sequence of heparin, were synthesized via coupling of a pair of disaccharide trichloroacetimidates with a thioglycoside and a glucosamine derivative, respectively, in a sequential manner.

A facile preparation of uronates via selective oxidation with TEMPO/KBr/Ca(OCl)2 under aqueous conditions

Addition of solid Ca(OCl)2 as the terminal oxidant in the TEMPO-mediated selective oxidation has the benefit of easier operation. A variety of partially protected saccharide derivatives (1a-l) have been successfully converted into the corresponding uronate derivatives, including disaccharide building blocks for GAG fragments and precursors to saponins. The beneficial effect of Aliquat 336 was also disclosed in the oxidation of certain substrates.