69788-30-3Relevant academic research and scientific papers
Spasmolytic Agents. 2. 1,2,3,4-Tetrahydro-2-naphthylamine Derivatives
Kanao, Munefumi,Hashizume, Takeshi,Ichikawa, Yoshifumi,Irie, Kiyoshi,Isoda, Sumiro
, p. 1358 - 1363 (2007/10/02)
N--1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines evaluated for their spasmolytic activity.Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were found to be equal to or more active than the reference drug (mebeverine).The biological data have indicated some structure-activity relationships.Among these compounds, N-ethyl-N-hexyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride (63) was found to be the most active spasmolytic agent.
2-Aminotetralin derivatives and process for producing the same
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, (2008/06/13)
Compounds, which have antispasmodic effects, represented by the following formula (I) STR1 wherein R 1 and R 2, which may be the same or different, each represents a hydrogen atom, an alkoxy group or, when taken together, R 1 and R 2 represent an alkylenedioxy group; R 3 represents a hydrogen atom, an alkyl group or a cycloalkyl group; R 4, R 5 and R 6, which may be the same or different, each represents a hydrogen atom, an alkoxy group, an alkyl group, a halogen atom, a hydroxyl group or, when two of R 4, R 5 and R 6 are taken together, they represent an alkylenedioxy group; and A represents a straight or branched chain alkylene group having 2 to 10 carbon atoms or an alkylene group having 2 to 10 carbon atoms and interrupted with an oxygen atom forming an ether bond therein, and the therapeutically useful acid-addition salts thereof; and a process for producing the same.
