6979-01-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Hydrazinylethyl)piperidine is used as an antiemetic agent for preventing chemotherapy-induced nausea and vomiting. Its dual mechanism of action, combining the effects of a neurokinin-1 receptor antagonist and a serotonin 5-HT3 receptor antagonist, makes it highly effective in managing these side effects. NEPA is well-tolerated and has shown to be more effective than traditional antiemetic drugs, making it a promising option for cancer patients undergoing chemotherapy.

Upstream product

• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 

Relevant academic research and scientific papers

2-Pyrazolin-5-ones bearing a basic dialkylaminoalkyl substituent at the N1-position: Preparation and NMR spectroscopic investigations

2-Pyrazolin-5-ones (= tautomers to 5-hydroxypyrazols) bearing dialkylaminoyalkyl substituents at the ring nitrogen atom N-1 are prepared from the corresponding hydrazines and beta-ketoesters. Detailed NMR spectroscopic investigations (1H,

Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs

In the constant search for new compounds endowed with antitumor activity we have synthesized a series of anthraquinone hydrazones, which can be seen either as opened-cycle modified anthrapyrazoles or as chromophore-modified anthracenediones. Seven 9,10-anthraquinone monoalkylaminoalkylhydrazones (3c-i) were synthesized from 10,10-dibromoanthrone (4) and a suitable N-alkylhydrazine. The hydrazones were converted into hydrochlorides and tested for their cytotoxic activity against L1210 murine leukemia cells. Two of them possess marginal activity in vitro.