69791-23-7Relevant academic research and scientific papers
Novel reaction products from thiobarbituric acid of biological interest
Aly, Ashraf A.,Mourad, Aboul-Fetouh E.,Hassan, Alaa A.,Mohamed, Nasr K.,Ali, Bahaa A.,El-Sayed, Mohamed M.
, p. 133 - 139 (2004)
The reactions of 1,2-dihydro-2-thioxo-4,6(1H,5H)pyrimidinedione (1) with some π-deficients have led to the formation of unexpected heterocyclic products such as anilinomethylenethioxopyrimidinedione, 2,2′- bis(pyrimidinecarbothioamide), allylthioxopyrimidinecarbothioamide, indenopyranopyrimidine and benzofuropyrimidine derivatives. A possible mechanism for the formation of these products is discussed, and the biological activity is determined.
New thiobarbituric acid scaffold-based small molecules: Synthesis, cytotoxicity, 2D-QSAR, pharmacophore modelling and in-silico ADME screening
El-Zahabi, Heba S.A.,Khalifa, Maha M.A.,Gado, Yomna M.H.,Farrag, Amel M.,Elaasser, Mahmoud M.,Safwat, Nesreen A.,AbdelRaouf, Reham R.,Arafa, Reem K.
, p. 124 - 136 (2019/02/03)
A series of twenty five new thiobarbituric acid derivatives, viz. 3a-h, 4–7, 8a-c, 9, 10a-c, 11 and 12a-d, were designed and synthesized as potential cytotoxic agents. In-vitro screening of the new compounds against the three human cancer cell lines Caco-
