69792-85-4

Basic information

• Product Name: 5-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole
• Synonyms: 5-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole
• CAS NO: 69792-85-4
• Molecular Weight: 325.581
• Mol File: 69792-85-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole(69792-85-4)
• EPA Substance Registry System: 5-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole(69792-85-4)

Safety Data

• Hazardous Substances Data: 69792-85-4(Hazardous Substances Data)

Upstream product

• 5033-28-3 4-chloro-N-hydroxybenzimidamide 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 5033-28-3 4-chlorobenzamidoxime 

Relevant articles and documents

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor

Bis-aryloxadiazoles are common scaffolds in medicinal chemistry due to their wide range of biological activities. Previously, we identified a 1,2,4-bis-aryloxadiazole that blocks mammary branching morphogenesis through activation of the aryl hydrocarbon receptor (AHR). In addition to defects in mammary differentiation, AHR stimulation induces toxicity in many other tissues. We performed a structure activity relationship (SAR) study of 1,2,4-bis-aryloxadiazole to determine which moieties of the molecule are critical for AHR activation. We validated our results with a functional biological assay, using desmosome formation during mammary morphogenesis to indicate AHR activity. These findings will aid the design of oxadiazole derivative therapeutics with reduced off-target toxicity profiles.