69796-46-9

Usage

Uses

Used in Pharmaceutical Industry:
5-BENZYLOXY-3-(2-NITROVINYL)-INDOLE is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 5-BENZYLOXY-3-(2-NITROVINYL)-INDOLE is utilized as a precursor in the production of agrochemicals, potentially leading to the creation of novel pesticides or other agricultural chemicals.
Used in Materials Science:
5-BENZYLOXY-3-(2-NITROVINYL)-INDOLE is employed as a component in the research and development of new materials, possibly contributing to advancements in areas such as polymer science or the creation of new composite materials.

InChI:InChI=1/C17H14N2O3/c20-19(21)9-8-14-11-18-17-7-6-15(10-16(14)17)22-12-13-4-2-1-3-5-13/h1-11,18H,12H2/b9-8-

Upstream product

• 75-52-5 nitromethane 
• 6953-22-6 5-benzyloxyindole-3-carboxaldehyde 

Downstream Products

• 5599-43-9 5-benzyloxy-N_b-formyltryptamine 
• 20776-45-8 5-benzyloxytryptamine 
• 1554471-86-1 4-(1-(5-(benzyloxy)-1H-indol-3-yl)-2-nitroethyl)-2-bromoaniline 
• 1554471-76-9 4-(1-(5-(benzyloxy)-1H-indol-3-yl)-2-nitroethyl)-2-iodoaniline 

Relevant academic research and scientific papers

Anti-tumor compounds

The invention discloses anti-tumor compounds. The compounds target a Neddylation pathway. The compounds have a structural formula represented in a general formula I or a general formula II or a general formula III or a general formula IV or a general formula V or a general formula VI. The compounds have good anti-tumor activity, and multiple compounds are close to a positive control drug MLN4924,and can be used as good anti-tumor compounds. A combined therapy is provided through combined adoption of the compounds and compositions with other drugs, and a part of the same compositions can be formed by the drugs, or the drugs can be administered as separate components at the same time or at different time.

Asymmetric dearomatization of indoles through a Michael/Friedel-Crafts-Type cascade to construct polycyclic spiroindolines

A highly efficient asymmetric dearomatization of indoles was realized through a cascade reaction between 2-isocyanoethylindole and alkylidene malonates catalyzed by a chiral N,N-dioxide/MgII catalyst. Fused polycyclic indolines containing three stereocenters were afforded in good yields with excellent diastereo- and enantioselectivities through a Michael/Friedel-Crafts/Mannich cascade. When 2-substituted 2-isocyanoethylindoles were used, spiroindoline derivatives were obtained through a Michael/Friedel-Crafts reaction.