69797-59-7Relevant academic research and scientific papers
Rational Optimization of Lewis-Acid Catalysts for Direct Alcohol Amination, Part 2 – Titanium Triflimide as New Active Catalyst
Payard, Pierre-Adrien,Finidori, Céline,Guichard, Laurélia,Cartigny, Damien,Corbet, Matthieu,Khrouz, Lhoussain,Bonneviot, Laurent,Wischert, Raphael,Grimaud, Laurence,Pera-Titus, Marc
supporting information, p. 3225 - 3228 (2020/06/08)
The reactivity of a new titanium triflimide salt (see Part 1) was investigated for the direct amination of alcohols. The combination of this new Lewis acid with pyridine-based ligands allowed a significant increase of activity. The scope of the reaction was increased compared to other Lewis-acid-based protocols. Finally, mechanistic insights based on EPR spectroscopy and DFT calculations are provided.
First efficient two-step/one-pot zirconium (IV)isopropoxide-mediated reductive amination of carbonyl compounds
Pieri, Cyril,Brunel, Jean Michel
, p. 448 - 456 (2015/06/22)
An efficient method for the synthesis of various primary and secondary amines through a zirconium(IV) isopropoxide-mediated reductive amination reaction of aldehydes and ketones is reported. A series of different aldehydes, ketones and amines were used leading to the expected amino products in moderate to excellent yields. The mechanistic rationale of this reaction has been postulated through the formation of a transient imine species and a diastereoselective version using (R)-phenylethylamine as chiral inducer led to the expected products in moderate to excellent yields and with diastereoselectivities up to 100%.
Synthesis of N-citralbenzenamines by NaBH4/B(OH)3 system
Setamdideh, Davood,Minaee, Mohsen
, p. 359 - 360 (2014/06/23)
Citral as α, β -unsaturated carbonyl compound has been reacted with structurally different anilines with sodium borohydride in the presence of boric acid for the synthesis of their corresponding Akatralbenzenamineswith good yields (75-85%)within 5 min in
Synthesis of α,α-disubstituted aryl amines by rhodium-catalyzed amination of tertiary allylic trichloroacetimidates
Arnold, Jeffrey S.,Cizio, Gregory T.,Nguyen, Hien M.
supporting information; experimental part, p. 5576 - 5579 (2011/12/04)
The rhodium-catalyzed regioselective amination of tertiary allylic trichloroacetimidates with unactivated aromatic amines is a direct and efficient approach to the preparation of α,α-disubstituted allylic aryl amines in good yield and with excellent regio
