69812-30-2

Basic information

• Product Name: 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI)
• Synonyms: 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI);2-(acetylamino)-1,3-thiazole-5-sulfonyl chloride(SALTDATA: FREE);2-(acetylamino)-5-thiazolesulfonylchloride;2-ACETAMIDOTHIAZOLE-5-SULFONYL CHLORIDE
• CAS NO: 69812-30-2
• Molecular Formula: C₅H₅ClN₂O₃S₂
• Molecular Weight: 240.69
• Product Categories: SULFONYLHALIDE
• Mol File: 69812-30-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.696 g/cm³
• Refractive Index: 1.612
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI)(69812-30-2)
• EPA Substance Registry System: 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI)(69812-30-2)

Safety Data

• Hazardous Substances Data: 69812-30-2(Hazardous Substances Data)

Usage

General Description

5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI) is a chemical compound with the molecular formula C6H6ClN3O2S2. It is a sulfonyl chloride derivative containing a thiazole ring and an acetylamino group. 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI) is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical products. It is known for its ability to undergo a variety of chemical reactions, making it a versatile intermediate in organic synthesis. Additionally, it is used as a reagent in the preparation of thiazole and sulfonamide derivatives, and it has potential applications as an intermediate in the production of dyes and pigments. Overall, 5-Thiazolesulfonylchloride,2-(acetylamino)-(9CI) has important industrial and research applications due to its unique chemical properties and reactivity.

InChI:InChI=1/C5H5ClN2O3S2/c1-3(9)8-5-7-2-4(12-5)13(6,10)11/h2H,1H3,(H,7,8,9)

Upstream product

• 2719-23-5 2-acetamidothiazole 

Downstream Products

• 1269500-26-6 C₂₀H₂₇N₅O₆S₂ 
• 920313-42-4 C₇H₁₁N₃O₃S₂ 
• 1036386-11-4 N-{5-[3-(2-amino-4-ethoxy-pyrido[3,2-d]pyrimidin-6-yl)-phenylsulfamoyl]-thiazol-2-yl}-acetamide 
• 159895-68-8 3-(2-Acetamido-5-thiazolesulfonamido)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol 
• 82971-10-6 2-amino-1,3-thiazole-5-sulfonic acid 

Relevant articles and documents

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cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Synthesis of sulofenur analoges as antitumour agents: Part II

A series of N-aryl-N′-heteroaryl or N,N′-diheteroaryl sulfonylurea has been prepared using two different methods. All the intermediates were prepared including heteroarylsulfonyl chlorides and aryl- or hetero-arylurea derivatives. Structural elucidation of the newly synthesized compounds were based on elementary analysis, IR, 1H & 1C NMR and mass spectra. The antitumor screening of the prepared compounds were performed at the National Cancer Institute (NCI) Bethesda, Maryland, USA. Compound N-(3-methylbenzothiazol-2-yl)-N′ -(1-benzodiazolyl-sulfonyl)urea (13) with GI50, TGI, LC50 (MG-MID) values of 25.1, 77.5, 93.3 μM, respectively is the most active compound in this study. It showed a broad spectrum antitumor activity as well as selective activity toward individual cell lines. It showed distinctive activities compared to that of sulofenur against RPMI-8226 leukemia, EKVX Non-small lung cancer, PC-3 prostate cancer, OVCAR-4 Ovarian cancer, CAKI-1Renal cancer, MDA-MB-435 and T-47D Breast cancer with GI50 values of 21.5, 1.7, 28.7, 25.9, 15.9, 27.9, 15.1 μM, respectively.