69822-88-4

Usage

Uses

Used in Pharmaceutical Manufacturing:
Cefuroxime Sodium EP Impurity C is used as a quality control parameter in the manufacturing process of cefuroxime sodium. It is monitored and controlled to ensure the purity and quality of the final drug product, meeting regulatory and safety standards.
Used in Drug Safety and Efficacy Analysis:
Cefuroxime Sodium EP Impurity C is used as an analytical target in methods such as chromatography and spectroscopy to determine its presence and concentration in the drug. This analysis helps ensure the safety and efficacy of cefuroxime sodium for medical use, preventing any potential adverse effects due to impurities.

Upstream product

• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 

Relevant academic research and scientific papers

To carboxamide [...] preparation method (by machine translation)

The invention discloses a de-carboxamide [...] preparation method, which comprises: separately preparing 7 - ADCA of the inorganic alkali aqueous solution and is - [...] - 2 - furan acetyl chloride solution, then the acyl chloride solution is added 7 - ADCA aqueous solution, control pH7.0 - 8.0 reaction, after the reaction standstill phase separation, the aqueous phase is added in ethanol or methanol, then adding dichloromethane, then adjusting the pH to 2.0 standing after phase separation, the organic phase containing the product of the concentrated to viscous, water crystallization, filtration, washing, drying the product is obtained. Due to the direct the approach to the protection of the main raw materials [...] sodium salt of 7 - ADCA, eliminates the tedious organic compound protection, late stage can be avoided-protecting group of the tedious step again, simplifies the synthetic method, the conversion and yield of the product, the molar yield of 92%; by controlling the pH value of the condensation, the reaction by-product trans-acetyl [...] under control, the reaction end-content is less than 0.1%, thereby improving the purity of the product, the purity of the product can be improved to 98.5%. (by machine translation)