69824-93-7Relevant academic research and scientific papers
Electrophilic Trapping of Zirconium Enolates Obtained by Copper-Catalyzed Addition of In Situ Generated Organozirconium Reagents
Némethová, Ivana,Sorádová, Zuzana,?ebesta, Radovan
, p. 2461 - 2469 (2017)
Building complex structures from simple starting materials is important for effective organic synthesis. In this context, domino reactions comprising hydrozirconation of alkenes, their subsequent utilization in a copper-catalyzed conjugate addition to enones, followed by electrophilic trapping of the formed zirconium enolates with activated alkene and carbocations are described. Reactivity of metal enolates was studied by DFT calculations.
Indium/copper-mediated conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds in water
Shen, Zhi-Liang,Cheong, Hao-Lun,Loh, Teck-Peng
supporting information; scheme or table, p. 1051 - 1054 (2009/05/27)
An efficient method for the conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl3
Direct Copper(I) Iodide Dimethyl Sulfide Catalyzed Conjugate Addition of Alkenyl Groups from Vinylzirconocene Reagents
El-Batta, Amer,Hage, Taleb R.,Plotkin, Steve,Bergdahl, Mikael
, p. 107 - 110 (2007/10/03)
(Equation presented) Cul·0.75DMS complex is an excellent catalyst for the direct conjugate addition of alkenyl groups from vinylzirconocene reagents to αβ-unsaturated aldehydes and ketones. The presence of the catalyst with an alkenylzirconocene, at +40°C in THF, circumvents the need for making discrete alkenylcopper reagents. The catalyst is superior in terms of product yields and alkene flexibility in comparison to other copper(I) sources as well as the nickel(II)-catalyzed conjugate addition. This simple one-pot procedure shows that only 1 equiv of the vinylzirconocene is needed.
