698352-87-3Relevant academic research and scientific papers
Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides
Marson, Charles M.,Savy, Pascal,Rioja, Alphonse S.,Mahadevan, Thevaki,Mikol, Catherine,Veerupillai, Arthi,Nsubuga, Eva,Chahwan, Angela,Joel, Simon P.
, p. 800 - 805 (2007/10/03)
The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamicles and their derivatives. In vitro IC50 values clown to 40 nM were obtained, and several compounds showed inhibition of CEM (human leukemic) cell viability with IC50 of ～1.5 μM, comparable to or better than that of suberoylatiilide hydroxamic acid, an inhibitor of histone cleacetylase currently in clinical trials.
HISTONE DEACETYLASE INHIBITORS
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Page 63-64, (2008/06/13)
The present invention provides histone deacetylase inhibitors of general formula (I), process for the preparation of such compounds and uses of the compounds in medicine.
