69836-98-2Relevant academic research and scientific papers
QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity
Gomes, Marcelo N.,Braga, Rodolpho C.,Grzelak, Edyta M.,Neves, Bruno J.,Muratov, Eugene,Ma, Rui,Klein, Larry L.,Cho, Sanghyun,Oliveira, Guilherme R.,Franzblau, Scott G.,Andrade, Carolina Horta
, p. 126 - 138 (2017/06/06)
New anti-tuberculosis (anti-TB) drugs are urgently needed to battle drug-resistant Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment regimen. In this work, we have continued the efforts to develop chalcone-based anti-TB co
Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation
Satheesha Rai,Kalluraya, Balakrishna,Lingappa,Shenoy, Shaliny,Puranic, Vedavati G.
, p. 1715 - 1720 (2008/12/20)
Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
