698374-97-9Relevant academic research and scientific papers
Microwave-assisted efficient synthesis of benzo[4,5]imidazo[1,2-a] pyrimidine derivatives in water under catalyst-free conditions
Tu, Shujiang,Shao, Qingqing,Zhou, Dianxiang,Cao, Longji,Shi, Feng,Li, Chunmei
, p. 1401 - 1406 (2007)
(Chemical Equation Presented) Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized via the three-component reaction of aldehyde, β-dicarbonyl compound and 2-aminobenzimidazole in water under microwave irradiation and without catalyst conditions. The new protocol has the advantages of higher yield, lower cost, reduced environment impact, wider scope and convenient procedure.
Preparation method of medical intermediate dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine derivative
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Paragraph 0035-0037; 0055-0056, (2020/07/02)
The invention discloses a preparation method of a medical intermediate, namely a dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine derivative, belonging to the technical field of biological medicines. The method comprises the following steps: taking aromatic alde
Three-component synthesis of 4-aryl-1H-pyrimido[1,2-a] benzimidazole derivatives in ionic liquid
Yao, Changsheng,Lei, Song,Wang, Cuihua,Li, Tuanjie,Yu, Chenxia,Wang, Xiangshan,Tu, Shujiang
experimental part, p. 26 - 32 (2010/05/03)
(Chemical Equation Presented) A green and simple synthesis of 4-ayrl-3,4-dihydro-1H-pyrimido[1,2-a]benzimidazole derivatives was accomplished in excellent yields via the reaction of aryl aldehyde, 1,3-dicarbonyl compounds and 1Hbenzo[ d]imidazol-2-amine in ionic liquid of [bmim+][BF 4- ]. This protocol has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure compared with the reported methods.
